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Pyruvate kinase M2 regulates Hif-1 activity and IL-1 induction and is a critical determinant of the warburg effect in LPS-activated macrophages

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For instance, some tripeptides promote fibroblast activity and collagen deposition [59, 61-64], while others enhance angiogenesis and modulate inflammation to accelerate tissue regeneration [58, 60, 65, 66]

This effect requires developmental mitochondrial superoxide, which downregulates SBP-1 (SREBP orthologue) and suppresses unsaturated fatty acid biosynthesis